Ischaemic heart disease is a leading cause of death in the Western world. Myocardial perfusion imaging (MPI) has become the most useful technique in selecting patients for further examination with coronary angiography and revascularisation. MPI can define low-risk patients, whose outcomes cannot be improved, therefore requiring no further evaluation.
Our contribution in this field has been the development of improved methods for automated analysis of MPI scans. We have presented new image processing and artificial intelligence techniques, and established normal database of MPI scans. A cardiac toolbox based on our research is widely used in Japan.
Publications
Nakajima K, Okuda K, Watanabe S, Matsuo S, Kinuya S, Toth K, Edenbrandt L. Artificial neural network retrained to detect myocardial ischemia using a Japanese multicenter database. Ann Nucl Med. 2018 Jun;32(5):303-310.
Nakajima K, Kudo T, Nakata T, Kiso K, Kasai T, Taniguchi Y, Matsuo S, Momose M, Nakagawa M, Sarai M, Hida S, Tanaka H, Yokoyama K, Okuda K, Edenbrandt L. Diagnostic accuracy of an artificial neural network compared with statistical quantitation of myocardial perfusion images: a Japanese multicenter study. Eur J Nucl Med Mol Imaging. 2017 Dec;44(13):2280-2289.
Yoneyama H, Nakajima K, Okuda K, Matsuo S, Onoguchi M, Kinuya S, Edenbrandt L. Reducing the small-heart effect in pediatric gated myocardial perfusion single-photon emission computed tomography. J Nucl Cardiol. 2016 May 19. [Epub ahead of print]
Trägårdh E, Ljungberg M, Edenbrandt L, Örndahl E, Johansson L, Gustafsson A, Jonsson C, Hagerman J, Riklund K, Minarik D. Evaluation of inter-departmental variability of ejection fraction and cardiac volumes in myocardial perfusion scintigraphy using simulated data. EJNMMI Phys. 2015 Dec;2(1):2.
Minarik D, Senneby M, Wollmer P, Mansten A, Sjöstrand K, Edenbrandt L, Trägårdh E. Perfusion vector-a new method to quantify myocardial perfusion scintigraphy images: a simulation study with validation in patients. EJNMMI Res. 2015 Dec;5(1):121.
Nakajima K, Matsuo S, Wakabayashi H, Yokoyama K, Bunko H, Okuda K, Kinuya S, Nyström K, Edenbrandt L. Diagnostic Performance of Artificial Neural Network for Detecting Ischemia in Myocardial Perfusion Imaging. Circ J. 2015;79(7):1549-56.
Trägårdh E, Hesse B, Knuuti J, Flotats A, Kaufmann PA, Kitsiou A, Hacker M, Verberne HJ, Edenbrandt L, Delgado V, Donal E, Edvardsen T, Galderisi M, Habib G, Lancellotti P, Nieman K, Rosenhek R; EACVI, Agostini D, Gimelli A, Lindner O, Slart R, Ubleis C; EANM. Reporting nuclear cardiology: a joint position paper by the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI). Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):272-9.
Trägårdh E, Carlsson M, Edenbrandt L. Computerized decision making in myocardial perfusion SPECT: The new era in nuclear cardiology? J Nucl Cardiol. 2015 Oct;22(5):885-7.
Edenbrandt L, Höglund P, Frantz S, Hasbak P, Johansen A, Johansson L, Kammeier A, Lindner O, Lomsky M, Matsuo S, Nakajima K, Nyström K, Olsson E, Sjöstrand K, Svensson SE, Wakabayashi H, Trägårdh E. Area of ischemia assessed by physicians and software packages from myocardial perfusion scintigrams. BMC Med Imaging. 2014 Jan 31;14:5.
Johansson L, Edenbrandt L, Nakajima K, Lomsky M, Svensson SE, Trägårdh E. Computer-aided diagnosis system outperforms scoring analysis in myocardial perfusion imaging. J Nucl Cardiol. 2014 Jun;21(3):416-23.
Edenbrandt L, Ohlsson M, Trägårdh E. Prognosis of patients without perfusion defects with and without rest study in myocardial perfusion scintigraphy. EJNMMI Res. 2013 Jul 31;3:58.
Nakajima K, Okuda K, Nyström K, Richter J, Minarik D, Wakabayashi H, Matsuo S, Kinuya S, Edenbrandt L. Improved quantification of small hearts for gated myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2013 Aug;40(8):1163-70.
Trägårdh E, Valind S, Edenbrandt L. Adding attenuation corrected images in myocardial perfusion imaging reduces the need for a rest study. BMC Med Imaging. 2013 Apr 1;13:14.
Johansen A, Lomsky M, Gerke O, Edenbrandt L, Johansson L, Hansen G, Jensen B, Reid MS, Johansson LL, Olofsson C, Minarik D, Nyström K, Wollmer P, Trägårdh E. When is reacquisition necessary due to high extra-cardiac uptake in myocardial perfusion scintigraphy? EJNMMI Res. 2013 Mar 25;3(1):20.
Trägårdh E, Sjöstrand K, Edenbrandt L. Normal stress databases in myocardial perfusion scintigraphy--how many subjects do you need? Clin Physiol Funct Imaging. 2012 Nov;32(6):455-62.
Trägårdh E, Johansson L, Olofsson C, Valind S, Edenbrandt L. Nuclear medicine technologists are able to accurately determine when a myocardial perfusion rest study is necessary. BMC Med Inform Decis Mak. 2012 Sep 4;12:97.
Trägårdh E, Höglund P, Ohlsson M, Wieloch M, Edenbrandt L. Referring physicians underestimate the extent of abnormalities in final reports from myocardial perfusion imaging. EJNMMI Res. 2012 Jun 9;2(1):27.
Johansson L, Lomsky M, Marving J, Ohlsson M, Svensson S-E, Edenbrandt L. Diagnostic evaluation of three cardiac software packages using a consecutive group of patients. EJNMMI Research. 1:2, 2011.
Tragardh E, Sjostrand K, Jakobsson D, Edenbrandt L. Small average differences in attenuation corrected images between men and women in myocardial perfusion scintigraphy: a novel normal stress database. BMC Med Imaging. Oct 3;11(1):18, 2011.
Gjertsson P, Johansson L, Lomsky M, Ohlsson M, Underwood SR, Edenbrandt L. Clinical data do not improve artificial neural network interpretation of myocardial perfusion scintigraphy. Clin Physiol Funct Imaging. May;31(3):240-5, 2011. Epub 2011 Jan 31.
Johansson L, Lomsky M, Gjertsson P, Sallerup-Reid M, Johansson J, Ahlin NG, Edenbrandt L. Can Nuclear Medicine Technologists Assess Whether a Myocardial Perfusion Rest Study Is Required? J Nucl Med Technol. 36:181-5, 2008
Gjertsson P, Ekberg S, Lomsky M, Gan L-M, Edenbrandt L. Evaluation of new automated gated-SPECT and echocardiographic methods for calculating left ventricular volumes and ejection fraction. Int J Cardiol. 14;136(2):171-7, 2009
Tägil K, Marving J, Lomsky M, Hesse B, Edenbrandt L. Use of neural networks to improve quality control of interpretations in myocardial perfusion imaging. Int J Cardiovasc Imaging. Dec;24(8):841-8, 2008
Tägil K, Bondouy M, Chaborel JP, Djaballah W, Franken PR, Grandpierre S, Hesse B, Lomsky M, Marie PY, Poisson T, Edenbrandt L. A decision support system improves the interpretation of myocardial perfusion imaging. 2008. Eur J Nucl Med Mol Imaging. Sep;35(9):1602-7, 2008
Lomsky M, Gjertsson P, Johansson L, Richter J, Ohlsson M, Tout D, van Aswegen A, Underwood SR, Edenbrandt L. Evaluation of a decision support system for interpretation of myocardial perfusion gated SPECT. Eur J Nucl Med Mol Imaging. Aug;35(8):1523-9, 2008
Lomsky M, Johansson L, Gjertsson P, Björk J, Edenbrandt L. Normal limits for left ventricular ejection fraction and volumes determined by gated SPECT – a comparison between two quantification methods. Clin Physiol Funct Imaging. Apr;28(3):169-73, 2008
Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, McKiddie F, Schaefer WM, Stegger L, Underwood R. EANM/ESC guidelines for radionuclide imaging of cardiac function. Eur J Nucl Med Mol Imaging. Apr;35(4):851-85, 2008
Gjertsson P, Lomsky M, Richter J, Ohlsson M, Tout D, van Aswegen A, Underwood R, Edenbrandt L. The added value of ECG-gating for the diagnosis of myocardial infarction using myocardial perfusion scintigraphy and artificial neural networks. Clin Physiol Funct Imaging 26, 5, 301-4, 2006
Tagil K, Underwood R, Davies G, Latus KA, Ohlsson M, Gotborg CW, Edenbrandt L. Patient gender and radiopharmaceutical tracer is of minor importance for the interpretation of myocardial perfusion images using an artificial neural network. Clin Physiol Funct Imaging. May;26(3):146-50, 2006
Lomsky M, Richter J, Johansson L, Hoilund-Carlsen PF, Edenbrandt L. Validation of a new automated method for analysis of gated-SPECT images. Clin Physiol Funct Imaging. May;26(3):139-45, 2006
El-Ali HH, Palmer J, Edenbrandt L, Ljungberg M. A model that accounts for the interdependence of extent and severity in the automatic evaluation of myocardial defects. Nucl Med Commun. Feb;27(2):127-35, 2006
El-Ali HH, Palmer J, Carlsson M, Edenbrandt L, Ljungberg M. Interdependence between measures of extent and severity of myocardial perfusion defects provided by automatic quantification programs. Nucl Med Commun. Dec;26(12):1125-30, 2005
Anagnostopoulos C, Bardiés M, Bax J, Bengel F, Busemann Sokole E, Cuocolo A, Davies G, Dondi M, Edenbrandt L, Franken F, Hesse B, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie P Y, McKiddie F, O´Connor M, Prvulovich E, Tägil K, Underwood R, van Eck-Smit B. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging. 32:855-897, 2005.
Lomsky M, Richter J, Johansson L, El-Ali H, Åström K, Ljungberg M, Edenbrandt L. A new automated method for analysis of gated-SPECT images based on a three-dimensional heart shaped model. Clin Physiol Funct Imaging. 25:234-240, 2005